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Issue 29, 2012
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Practical biocatalytic desymmetrization of meso-N-heterocyclic dicarboxamides and their application in the construction of aza-sugar containing nucleoside analogs

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Abstract

Amidase-catalyzed desymmetrization of meso-N-heterocyclic dicarboxamides under very mild conditions provided a highly efficient and practical method for the preparation of enantiomerically pure carbamoyl-substituted heterocyclic amino acids that were unique and versatile platforms for the construction of both antipodes of aza-sugar containing nucleoside analogs.

Graphical abstract: Practical biocatalytic desymmetrization of meso-N-heterocyclic dicarboxamides and their application in the construction of aza-sugar containing nucleoside analogs

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Article information


Submitted
22 Dec 2011
Accepted
28 Jan 2012
First published
30 Jan 2012

Chem. Commun., 2012,48, 3482-3484
Article type
Communication

Practical biocatalytic desymmetrization of meso-N-heterocyclic dicarboxamides and their application in the construction of aza-sugar containing nucleoside analogs

P. Chen, M. Gao, D. Wang, L. Zhao and M. Wang, Chem. Commun., 2012, 48, 3482
DOI: 10.1039/C2CC18012J

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