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Issue 27, 2012
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Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid

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Abstract

A library of α2–3- and α2–6-linked sialyl galactosides containing C9-modified sialic acids was synthesized from C6-modified mannose derivatives using an efficient one-pot three-enzyme system. These sialosides were used in a high-throughput sialidase substrate specificity assay to elucidate the importance of C9–OH in sialidase recognition.

Graphical abstract: Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid

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Publication details

The article was received on 27 Nov 2011, accepted on 07 Feb 2012 and first published on 09 Feb 2012


Article type: Communication
DOI: 10.1039/C2CC17393J
Chem. Commun., 2012,48, 3357-3359

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    Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid

    Z. Khedri, M. M. Muthana, Y. Li, S. M. Muthana, H. Yu, H. Cao and X. Chen, Chem. Commun., 2012, 48, 3357
    DOI: 10.1039/C2CC17393J

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