Issue 9, 2012
From the journal:

Chemical Communications

A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe†

Barbara Albertoni,a   Jeffrey S. Hannam,a   Damian Ackermann,a   Anton Schmitza  and  Michael Famulok*a  

* Corresponding authors

a LIMES Institute, Chemical Biology & Medicinal Chemistry Unit, University of Bonn, 53121 Bonn, Germany
E-mail: m.famulok@uni-bonn.de
Fax: +49-228-735388

Abstract

The synthesis of a trifluoromethylphenyl diazirine photoaffinity probe of the cytohesin inhibitor SecinH3 is described. The probe exhibits improved labelling efficiency over a benzophenone-based probe and thus is more suitable for photoaffinity labelling in complex biological samples.

Graphical abstract: A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe

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Article information

DOI
https://doi.org/10.1039/C2CC16477A
Article type
Communication
Submitted
18 Oct 2011
Accepted
28 Nov 2011
First published
28 Nov 2011

Chem. Commun., 2012,48, 1272-1274

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A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe

B. Albertoni, J. S. Hannam, D. Ackermann, A. Schmitz and M. Famulok, Chem. Commun., 2012, 48, 1272 DOI: 10.1039/C2CC16477A

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