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Issue 17, 2012
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Fluorescent dye-doped silica nanoparticles: new tools for bioapplications

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Abstract

The need to decipher various biological events has led to the elucidation of the molecular mechanisms underlying a number of disease processes. Consequently, the detection and simultaneous monitoring of chemical interactions between biological targets has become indispensable in medical diagnosis, targeted therapeutics, and molecular biology. Multiplexed applications employing nanomaterials, which represent the integration of nanotechnology and biology, have changed the bioanalytical outlook and provided various promising tools. Among these nanomaterials, fluorescent dye-doped silica nanoparticles have demonstrated excellent potential for use in advanced bioanalysis to facilitate deeper understanding of biology and medicine at the molecular level. In particular, silica nanoparticles have been applied to diagnostics and therapeutic applications in cancer and gene/drug delivery. This feature article summarizes recent developments in the synthesis, biocompatibility, and bioapplications of fluorescent dye-doped silica nanoparticles.

Graphical abstract: Fluorescent dye-doped silica nanoparticles: new tools for bioapplications

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Publication details

The article was received on 11 Oct 2011, accepted on 14 Dec 2011 and first published on 14 Dec 2011


Article type: Feature Article
DOI: 10.1039/C2CC16306C
Citation: Chem. Commun., 2012,48, 2270-2282
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    Fluorescent dye-doped silica nanoparticles: new tools for bioapplications

    S. W. Bae, W. Tan and J. Hong, Chem. Commun., 2012, 48, 2270
    DOI: 10.1039/C2CC16306C

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