Jump to main content
Jump to site search

Issue 23, 2012
Previous Article Next Article

Enantioselective trapping of an α-chiral carbanion of acyclic nitrile by a carbon electrophile

Author affiliations

Abstract

An α-chiral nitrile carbanion generated by deprotonation of enantioenriched O-carbamoyl cyanohydrin was trapped in situ with ethyl cyanoformate to give the corresponding ester derivative in 92% yield and 90 : 10 er, providing the first example of trapping of an α-chiral acyclic nitrile carbanion that has been considered to be very configurationally labile.

Graphical abstract: Enantioselective trapping of an α-chiral carbanion of acyclic nitrile by a carbon electrophile

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Jan 2012, accepted on 27 Jan 2012 and first published on 30 Jan 2012


Article type: Communication
DOI: 10.1039/C2CC00082B
Citation: Chem. Commun., 2012,48, 2897-2899
  •   Request permissions

    Enantioselective trapping of an α-chiral carbanion of acyclic nitrile by a carbon electrophile

    M. Sasaki, T. Takegawa, H. Ikemoto, M. Kawahata, K. Yamaguchi and K. Takeda, Chem. Commun., 2012, 48, 2897
    DOI: 10.1039/C2CC00082B

Search articles by author

Spotlight

Advertisements