Jump to main content
Jump to site search

Issue 10, 2012
Previous Article Next Article

Diverse organo-peptide macrocyclesvia a fast and catalyst-free oxime/intein-mediated dual ligation

Author affiliations

Abstract

Macrocyclic Organo-Peptide Hybrids (MOrPHs) can be prepared from genetically encoded polypeptidesvia a chemoselective and catalyst-free reaction between a trifunctional oxyamino/amino-thiol synthetic precursor and an intein-fusion protein incorporating a bioorthogonal keto group.

Graphical abstract: Diverse organo-peptide macrocyclesvia a fast and catalyst-free oxime/intein-mediated dual ligation

Back to tab navigation

Supplementary files

Article information


Submitted
15 Jun 2011
Accepted
11 Aug 2011
First published
07 Sep 2011

Chem. Commun., 2012,48, 1461-1463
Article type
Communication

Diverse organo-peptide macrocyclesvia a fast and catalyst-free oxime/intein-mediated dual ligation

M. Satyanarayana, F. Vitali, J. R. Frost and R. Fasan, Chem. Commun., 2012, 48, 1461
DOI: 10.1039/C1CC13533C

Social activity

Search articles by author

Spotlight

Advertisements