Issue 91, 2012

Carbenoid-mediated N–O bond insertion and its application in the synthesis of pyridines

Abstract

Highly efficient synthesis of 3-hydroxypyridines has been developed based on carbenoid-mediated N–O bond insertion. Treatment of δ-diazo oxime ethers with dirhodium complex Rh2(tfacam)4 rapidly provides a variety of pyridines in 5–10 minutes in good to excellent yields.

Graphical abstract: Carbenoid-mediated N–O bond insertion and its application in the synthesis of pyridines

Supplementary files

Article information

Article type
Communication
Submitted
18 Aug 2012
Accepted
25 Sep 2012
First published
26 Sep 2012

Chem. Commun., 2012,48, 11244-11246

Carbenoid-mediated N–O bond insertion and its application in the synthesis of pyridines

X. Qi, L. Dai and C. Park, Chem. Commun., 2012, 48, 11244 DOI: 10.1039/C2CC36009H

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