Issue 90, 2012
From the journal:

Chemical Communications

Enabling Wittig reaction on site-specific protein modification†

Ming-Jie Han,a   De-Cai Xionga  and  Xin-Shan Ye*a  

* Corresponding authors

a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road No. 38, Beijing 100191, China
E-mail: xinshan@bjmu.edu.cn
Fax: +86 10 82802724
Tel: +86 10 82805736

Abstract

An efficient aqueous Wittig reaction was enabled on protein bioconjugation for the first time. By investigating the reaction on small molecules, peptides, and proteins, a site-specific reaction targeting “aldehyde tag” was presented. A variety of functional groups could be introduced into the protein of interest.

Graphical abstract: Enabling Wittig reaction on site-specific protein modification

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Article information

DOI
https://doi.org/10.1039/C2CC35738K
Article type
Communication
Submitted
08 Aug 2012
Accepted
24 Sep 2012
First published
25 Sep 2012

Chem. Commun., 2012,48, 11079-11081

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Enabling Wittig reaction on site-specific protein modification

M. Han, D. Xiong and X. Ye, Chem. Commun., 2012, 48, 11079 DOI: 10.1039/C2CC35738K

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