Issue 83, 2012

A regio- and diastereoselective palladium-catalyzed cyclopropanation of norbornene derivatives with molecular oxygen as the sole oxidant

Abstract

A mild and efficient Pd-catalyzed cyclopropanation of norbornene derivatives with tertiary propargylic alcohols using molecular oxygen as the sole oxidant is described. This process allows quick and atom-economical assembly of various 1,2,3-trisubstituted cyclopropanes bearing α,β-unsaturated ketone moieties in high yields as a single regio- and diastereoisomer.

Graphical abstract: A regio- and diastereoselective palladium-catalyzed cyclopropanation of norbornene derivatives with molecular oxygen as the sole oxidant

Supplementary files

Article information

Article type
Communication
Submitted
17 Jul 2012
Accepted
01 Sep 2012
First published
03 Sep 2012

Chem. Commun., 2012,48, 10340-10342

A regio- and diastereoselective palladium-catalyzed cyclopropanation of norbornene derivatives with molecular oxygen as the sole oxidant

W. Wu, H. Jiang, Y. Gao, H. Huang, W. Zeng and D. Cao, Chem. Commun., 2012, 48, 10340 DOI: 10.1039/C2CC35124B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements