Issue 84, 2012
From the journal:

Chemical Communications

Reengineered epipodophyllotoxin†

Igor V. Magedov,*a   Nikolai M. Evdokimov,a   Menuka Karki,b   Amanda S. Peretti,c   Dustin T. Lima,a   Liliya V. Frolova,a   Mary R. Reisenauer,c   Anntherese E. Romero,c   Paul Tongwa,d   Alexandr Fonari,d   Jeff Altig,a   Snezna Rogelj,c   Mikhail Yu. Antipin,d   Charles B. Shusterb  and  Alexander Kornienko*ae  

* Corresponding authors

a Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, USA
E-mail: imagedov@nmt.edu

b Department of Biology, New Mexico State University, Las Cruces, USA

c Department of Biology, New Mexico Institute of Mining and Technology, Socorro, USA

d Department of Biology and Chemistry, New Mexico Highlands University, Las Vegas, USA

e Department of Chemistry and Biochemistry, Texas State University – San Marcos, San Marcos, TX, USA
E-mail: a_k76@txstate.edu

Abstract

A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.

Graphical abstract: Reengineered epipodophyllotoxin

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Article information

DOI
https://doi.org/10.1039/C2CC35044K
Article type
Communication
Submitted
14 Jul 2012
Accepted
29 Aug 2012
First published
17 Sep 2012

Chem. Commun., 2012,48, 10416-10418

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Reengineered epipodophyllotoxin

I. V. Magedov, N. M. Evdokimov, M. Karki, A. S. Peretti, D. T. Lima, L. V. Frolova, M. R. Reisenauer, A. E. Romero, P. Tongwa, A. Fonari, J. Altig, S. Rogelj, M. Yu. Antipin, C. B. Shuster and A. Kornienko, Chem. Commun., 2012, 48, 10416 DOI: 10.1039/C2CC35044K

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