Issue 78, 2012
From the journal:

Chemical Communications

Reversible thermal transition of polydiacetylene based on KTTKS collagen sequence†

Pasquale Palladino,a   Valeria Castelletto,a   Ashkan Dehsorkhi,a   Dmitry Stetsenkoa  and  Ian W. Hamley*a  

* Corresponding authors

a School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AD, UK
E-mail: I.W.Hamley@reading.ac.uk
Fax: +44 (0)1183788450
Tel: +44 (0)1183786341

Abstract

Here we explore the physico-chemical properties of a peptide amphiphile obtained by chemical conjugation of the collagen-stimulating peptide KTTKS with 10,12-pentacosadiynoic acid which photopolymerizes as a stable and extended polydiacetylene. We investigate the self-assembly of this new polymer and rationalize its peculiar behavior in terms of a thermal conformational transition. Surprisingly, this polymer shows a thermal transition associated with a non-cooperative increase in β-sheet content at high temperature.

Graphical abstract: Reversible thermal transition of polydiacetylene based on KTTKS collagen sequence

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Article information

DOI
https://doi.org/10.1039/C2CC34665F
Article type
Communication
Submitted
29 Jun 2012
Accepted
12 Aug 2012
First published
13 Aug 2012

Chem. Commun., 2012,48, 9774-9776

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Reversible thermal transition of polydiacetylene based on KTTKS collagen sequence

P. Palladino, V. Castelletto, A. Dehsorkhi, D. Stetsenko and I. W. Hamley, Chem. Commun., 2012, 48, 9774 DOI: 10.1039/C2CC34665F

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