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Issue 95, 2012
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Recent trends in Cys- and Ser/Thr-based synthetic strategies for the elaboration of peptide constructs

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Abstract

Recent conceptual advances in the chemical synthesis of peptide constructs are described, encompassing native chemical ligation (i.e. the chemoselective covalent condensation of unprotected peptide segments) and O-, S-acyl isopeptide strategies (i.e. internal O,S-to-N acyl transfer within peptides).

Graphical abstract: Recent trends in Cys- and Ser/Thr-based synthetic strategies for the elaboration of peptide constructs

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Article information


Submitted
20 Jun 2012
Accepted
12 Sep 2012
First published
13 Sep 2012

Chem. Commun., 2012,48, 11601-11622
Article type
Feature Article

Recent trends in Cys- and Ser/Thr-based synthetic strategies for the elaboration of peptide constructs

J. M. Monbaliu and A. R. Katritzky, Chem. Commun., 2012, 48, 11601
DOI: 10.1039/C2CC34434C

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