Issue 78, 2012
From the journal:

Chemical Communications

Enantioselective aza-Henry reactions of cyclic α-carbonyl ketimines under bifunctional catalysis†

Alejandro Parra,a   Ricardo Alfaro,a   Leyre Marzo,a   Alberto Moreno-Carrasco,a   José Luis García Ruanoa  and  José Alemán*a  

* Corresponding authors

a Departamento de Química Orgánica (Módulo 1), Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid, Spain
E-mail: jose.aleman@uam.es

Abstract

The aza-Henry reaction of nitroalkanes with the C[double bond, length as m-dash]N group of 2-aryl-3H-indol-3-ones catalyzed by thiourea-chincona derivatives takes place with good yield and high ee's.

Graphical abstract: Enantioselective aza-Henry reactions of cyclic α-carbonyl ketimines under bifunctional catalysis

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Article information

DOI
https://doi.org/10.1039/C2CC34053D
Article type
Communication
Submitted
06 Jun 2012
Accepted
07 Aug 2012
First published
08 Aug 2012

Chem. Commun., 2012,48, 9759-9761

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Enantioselective aza-Henry reactions of cyclic α-carbonyl ketimines under bifunctional catalysis

A. Parra, R. Alfaro, L. Marzo, A. Moreno-Carrasco, J. L. García Ruano and J. Alemán, Chem. Commun., 2012, 48, 9759 DOI: 10.1039/C2CC34053D

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