Issue 68, 2012
From the journal:

Chemical Communications

A lateral flow biosensor for detection of single nucleotide polymorphism by circular strand displacement reaction†

Zhuo Xiao,‡a   Puchang Lie,‡a   Zhiyuan Fang,a   Luxin Yu,a   Junhua Chen,a   Jie Liu,a   Chenchen Ge,ab   Xuemeng Zhoua  and  Lingwen Zeng*a  

* Corresponding authors

a South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510663, China
E-mail: zeng6@yahoo.com

b University of Science and Technology of China, Hefei, China

Abstract

A lateral flow biosensor for detection of single nucleotide polymorphism based on circular strand displacement reaction (CSDPR) has been developed. Taking advantage of high fidelity of T4 DNA ligase, signal amplification by CSDPR, and the optical properties of gold nanoparticles, this assay has reached a detection limit of 0.01 fM.

Graphical abstract: A lateral flow biosensor for detection of single nucleotide polymorphism by circular strand displacement reaction

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Article information

DOI
https://doi.org/10.1039/C2CC33931E
Article type
Communication
Submitted
01 Jun 2012
Accepted
05 Jul 2012
First published
06 Jul 2012

Chem. Commun., 2012,48, 8547-8549

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A lateral flow biosensor for detection of single nucleotide polymorphism by circular strand displacement reaction

Z. Xiao, P. Lie, Z. Fang, L. Yu, J. Chen, J. Liu, C. Ge, X. Zhou and L. Zeng, Chem. Commun., 2012, 48, 8547 DOI: 10.1039/C2CC33931E

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