Issue 65, 2012

Enantioselective synthesis of levomilnacipran

Abstract

A novel approach for the asymmetric synthesis of the active (1S,2R)-enantiomer of the antidepressant milnacipran is reported. The two stereogenic centers borne by the cyclopropane ring were sequentially installed starting from phenylacetic acid.

Graphical abstract: Enantioselective synthesis of levomilnacipran

Supplementary files

Article information

Article type
Communication
Submitted
24 May 2012
Accepted
22 Jun 2012
First published
22 Jun 2012

Chem. Commun., 2012,48, 8111-8113

Enantioselective synthesis of levomilnacipran

J. Alliot, E. Gravel, F. Pillon, D. Buisson, M. Nicolas and E. Doris, Chem. Commun., 2012, 48, 8111 DOI: 10.1039/C2CC33743F

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