Structure-based tuning of Tm in lipid-like ionic liquids. Insights from Tf2N− salts of gene transfection agents

Arsalan Mirjafari; Samuel M. Murray; Richard A. O’Brien; Alexandra C. Stenson; Kevin N. West; James H. Davis

doi:10.1039/C2CC33609J

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Structure-based tuning of T_m in lipid-like ionic liquids. Insights from Tf₂N⁻ salts of gene transfection agents†

Arsalan Mirjafari,^a Samuel M. Murray,^b Richard A. O’Brien,^a Alexandra C. Stenson,^a Kevin N. West*^b and James H. Davis, Jr.*^a

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* Corresponding authors

^a Department of Chemistry, The University of South Alabama, Mobile, Alabama, USA
E-mail: jdavis@jaguar1.usouthal.edu
Fax: +1 251 460 7359
Tel: +1 251 460 7427

^b Department of Chemical & Biomolecular Engineering, The University of South Alabama, Mobile, Alabama 36688, USA
E-mail: kevinwest@southalabama.edu

Abstract

Ionic liquids of cations bearing two lipid-like aliphatic tails are shown to have values of T_m that can be very low, and that can be tuned up or down by the addition, deletion, or combination of dipolar modules and side-chain double bonds.

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Article information

DOI: https://doi.org/10.1039/C2CC33609J
Article type: Communication
Submitted: 18 May 2012
Accepted: 11 Jun 2012
First published: 13 Jun 2012

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Chem. Commun., 2012,48, 7522-7524

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Structure-based tuning of T_m in lipid-like ionic liquids. Insights from Tf₂N⁻ salts of gene transfection agents

A. Mirjafari, S. M. Murray, R. A. O’Brien, A. C. Stenson, K. N. West and J. H. Davis, Chem. Commun., 2012, 48, 7522 DOI: 10.1039/C2CC33609J

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