Issue 63, 2012
From the journal:

Chemical Communications

Organocatalyzed Michael–Henry reactions: enantioselective synthesis of cyclopentanecarbaldehydes via the dienamine organocatalysis of a succinaldehyde surrogate†

Bor-Cherng Hong,*a   Po-Yuan Chen,a   Prakash Kotame,a   Pei-Ying Lu,a   Gene-Hsiang Leeb  and  Ju-Hsiou Liaoa  

* Corresponding authors

a Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi 621, Taiwan, R.O.C
E-mail: chebch@ccu.edu.tw
Fax: +886 5 272104
Tel: +886 5 2428174

b Instrumentation Center, National Taiwan University, Taipei 106, Taiwan, R.O.C

Abstract

Asymmetric formal [3+2] cycloadditions of 4-hydroxybut-2-enal, a succinaldehyde surrogate, and nitroalkenes with an organocatalyst provided cyclopentanecarbaldehydes containing four consecutive stereogenic centers with excellent enantioselectivities.

Graphical abstract: Organocatalyzed Michael–Henry reactions: enantioselective synthesis of cyclopentanecarbaldehydes via the dienamine organocatalysis of a succinaldehyde surrogate

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Article information

DOI
https://doi.org/10.1039/C2CC33309K
Article type
Communication
Submitted
08 May 2012
Accepted
24 May 2012
First published
29 May 2012

Chem. Commun., 2012,48, 7790-7792

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Organocatalyzed Michael–Henry reactions: enantioselective synthesis of cyclopentanecarbaldehydes via the dienamine organocatalysis of a succinaldehyde surrogate

B. Hong, P. Chen, P. Kotame, P. Lu, G. Lee and J. Liao, Chem. Commun., 2012, 48, 7790 DOI: 10.1039/C2CC33309K

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