Issue 57, 2012
From the journal:

Chemical Communications

Synthetic mammalian riboswitches based on guanine aptazyme†‡

Yoko Nomura,a   Deepak Kumara  and  Yohei Yokobayashi*a  

* Corresponding authors

a Department of Biomedical Engineering, University of California Davis, 451 Health Sciences Drive, Davis, USA
E-mail: yoko@ucdavis.edu
Fax: +1 530 754 5739
Tel: +1 530 754 9676

Abstract

Allosteric hammerhead ribozymes (aptazymes) that are activated by guanine were used to control mammalian gene expression in cis and in trans. Coexpression of the two mechanistically distinct riboswitches resulted in an improved dynamic range of gene expression.

Graphical abstract: Synthetic mammalian riboswitches based on guanine aptazyme

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Article information

DOI
https://doi.org/10.1039/C2CC33140C
Article type
Communication
Submitted
02 May 2012
Accepted
29 May 2012
First published
30 May 2012

Chem. Commun., 2012,48, 7215-7217

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Synthetic mammalian riboswitches based on guanine aptazyme

Y. Nomura, D. Kumar and Y. Yokobayashi, Chem. Commun., 2012, 48, 7215 DOI: 10.1039/C2CC33140C

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