Issue 57, 2012
From the journal:

Chemical Communications

An activity-based fluorogenic probe for sensitive and selective monoamine oxidase-B detection†

Shaobo Long,a   Lin Chen,a   Yumi Xiang,a   Minggui Song,a   Yuguo Zhenga  and  Qing Zhu*a  

* Corresponding authors

a Institute of Bioengineering, Zhejiang University of Technology, Chaowang Road 18, China
E-mail: zhuq@zjut.edu.cn
Fax: +86-571-88320781
Tel: +86-571-88320781

Abstract

We report the design and synthesis of a new class of fluorogenic probes based on monoamine oxidase-triggered oxidative C–O bond cleavage. The selectivity of probe P1 towards MAO-B was 22-fold higher than that towards MAO-A.

Graphical abstract: An activity-based fluorogenic probe for sensitive and selective monoamine oxidase-B detection

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Article information

DOI
https://doi.org/10.1039/C2CC33089J
Article type
Communication
Submitted
29 Apr 2012
Accepted
21 May 2012
First published
12 Jun 2012

Chem. Commun., 2012,48, 7164-7166

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An activity-based fluorogenic probe for sensitive and selective monoamine oxidase-B detection

S. Long, L. Chen, Y. Xiang, M. Song, Y. Zheng and Q. Zhu, Chem. Commun., 2012, 48, 7164 DOI: 10.1039/C2CC33089J

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