Issue 57, 2012

An activity-based fluorogenic probe for sensitive and selective monoamine oxidase-B detection

Abstract

We report the design and synthesis of a new class of fluorogenic probes based on monoamine oxidase-triggered oxidative C–O bond cleavage. The selectivity of probe P1 towards MAO-B was 22-fold higher than that towards MAO-A.

Graphical abstract: An activity-based fluorogenic probe for sensitive and selective monoamine oxidase-B detection

Supplementary files

Article information

Article type
Communication
Submitted
29 Apr 2012
Accepted
21 May 2012
First published
12 Jun 2012

Chem. Commun., 2012,48, 7164-7166

An activity-based fluorogenic probe for sensitive and selective monoamine oxidase-B detection

S. Long, L. Chen, Y. Xiang, M. Song, Y. Zheng and Q. Zhu, Chem. Commun., 2012, 48, 7164 DOI: 10.1039/C2CC33089J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements