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Issue 51, 2012
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Facile preparation of non-self-quenching fluorescent DNA strands with the degree of labeling up to the theoretic limit

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Abstract

A new aggregation-induced emission (AIE) compound 1,1-dimethyl-2,5-bis[4-(isothiocyanatemethyl)phenyl]-3,4-diphenylsilole (SITC) was synthesized and used to conjugate with aminoallyl-dUTP. The SITC–dUTP can be incorporated enzymatically into DNA strands with the degree of labeling (DOL) up to the theoretic limit.

Graphical abstract: Facile preparation of non-self-quenching fluorescent DNA strands with the degree of labeling up to the theoretic limit

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Publication details

The article was received on 20 Mar 2012, accepted on 04 May 2012 and first published on 04 May 2012


Article type: Communication
DOI: 10.1039/C2CC32038J
Citation: Chem. Commun., 2012,48, 6360-6362

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    Facile preparation of non-self-quenching fluorescent DNA strands with the degree of labeling up to the theoretic limit

    Y. Yu, J. Liu, Z. Zhao, K. M. Ng, K. Q. Luo and B. Z. Tang, Chem. Commun., 2012, 48, 6360
    DOI: 10.1039/C2CC32038J

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