Issue 61, 2012
From the journal:

Chemical Communications

An aptazyme-based molecular device that converts a small-molecule input into an RNA output†

Shotaro Ayukawa,a   Yoko Sakai‡a  and  Daisuke Kiga*a  

* Corresponding authors

a Department of Computational Intelligence and Systems Science, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Yokohama, Midori-ku, Japan
E-mail: kiga@dis.titech.ac.jp
Fax: +81 45 924 5213
Tel: +81 45 924 5213

Abstract

We describe the construction of an aptazyme-based molecular device that converts, through a cascade of reactions, a small-molecule input into output RNA strands. This device is applicable as an interface between a small molecule and a molecular system that accepts only nucleic acid input.

Graphical abstract: An aptazyme-based molecular device that converts a small-molecule input into an RNA output

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Article information

DOI
https://doi.org/10.1039/C2CC31886E
Article type
Communication
Submitted
14 Mar 2012
Accepted
14 Apr 2012
First published
16 Apr 2012

Chem. Commun., 2012,48, 7556-7558

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An aptazyme-based molecular device that converts a small-molecule input into an RNA output

S. Ayukawa, Y. Sakai and D. Kiga, Chem. Commun., 2012, 48, 7556 DOI: 10.1039/C2CC31886E

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