Issue 45, 2012
From the journal:

Chemical Communications

Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties†

Colin L. Walsh,a   Juliane Nguyenb  and  Francis C. Szoka*ab  

* Corresponding authors

a The UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, CA, USA

b Department of Bioengineering and Therapeutic Sciences, UCSF, 513 Parnassus Ave, San Francisco, CA, USA
E-mail: szoka@cgl.ucsf.edu
Fax: (415) 476-0688
Tel: (415) 476-3895

Abstract

We report the synthesis and biophysical characterization of a novel class of zwitterionic lipids (ZL) with head groups containing a 3° or 4° amine and carboxylate. ZL form stable liposomes that exhibit head group dependent, pH-responsive biophysical characteristics. These lipids may be suitable components for drug delivery applications due to their ease of synthesis and unique pH-dependent properties.

Graphical abstract: Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties

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Article information

DOI
https://doi.org/10.1039/C2CC31710A
Article type
Communication
Submitted
07 Mar 2012
Accepted
10 Apr 2012
First published
11 Apr 2012

Chem. Commun., 2012,48, 5575-5577

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Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties

C. L. Walsh, J. Nguyen and F. C. Szoka, Chem. Commun., 2012, 48, 5575 DOI: 10.1039/C2CC31710A

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