Issue 41, 2012
From the journal:

Chemical Communications

Cascade signal amplification strategy for the detection of cancer cells by rolling circle amplification and nanoparticles tagging†

Caifeng Ding,*a   Haitao Liu,a   Nannan Wanga  and  Zhenfeng Wanga  

* Corresponding authors

a State Key Laboratory Base of Eco-chemical Engineering, Key Laboratory of Biochemical Analysis, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
E-mail: dingcaifeng2003@163.com
Fax: +86 532 84022750
Tel: +86 532 84022750

Abstract

A cascade signal amplification strategy was proposed for detection of cancer cells at ultralow concentration by combining the rolling circle amplification (RCA) technique with oligonucleotide functionalized nanoparticles (NPs), and anodic stripping voltammetric detection. This flexible biosensing system exhibited high sensitivity and specificity with the detection limits of 10 Ramos cells mL−1.

Graphical abstract: Cascade signal amplification strategy for the detection of cancer cells by rolling circle amplification and nanoparticles tagging

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Article information

DOI
https://doi.org/10.1039/C2CC31390A
Article type
Communication
Submitted
24 Feb 2012
Accepted
29 Mar 2012
First published
30 Mar 2012

Chem. Commun., 2012,48, 5019-5021

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Cascade signal amplification strategy for the detection of cancer cells by rolling circle amplification and nanoparticles tagging

C. Ding, H. Liu, N. Wang and Z. Wang, Chem. Commun., 2012, 48, 5019 DOI: 10.1039/C2CC31390A

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