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Issue 50, 2012
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Phthalocyanines: a new class of G-quadruplex-ligands with many potential applications

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Abstract

A G-quadruplex is a four-stranded DNA structure featuring stacked guanine tetrads, G-quartets. Formation of a G-quadruplex in telomere DNA can inhibit telomerase activity; therefore, development of G-quadruplex-ligands, which induce and/or stabilize G-quadruplexes, has become an area of great interest. Phthalocyanine derivatives have substantial potential as high-affinity G-quadruplex-ligands because these planar chromophores are similar in size and shape to the G-quartets. Here, we focus on the latest findings on phthalocyanine derivatives as G-quadruplex-ligands, and discuss the mechanisms by which phthalocyanines bind to G-quadruplexes with high affinity and selectivity. We also discuss potential biomedical and organic electronic applications of phthalocyanines that are dependent on their photophysical properties.

Graphical abstract: Phthalocyanines: a new class of G-quadruplex-ligands with many potential applications

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Publication details

The article was received on 13 Feb 2012, accepted on 17 Apr 2012 and first published on 18 Apr 2012


Article type: Feature Article
DOI: 10.1039/C2CC31037F
Citation: Chem. Commun., 2012,48, 6203-6216

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    Phthalocyanines: a new class of G-quadruplex-ligands with many potential applications

    H. Yaku, T. Fujimoto, T. Murashima, D. Miyoshi and N. Sugimoto, Chem. Commun., 2012, 48, 6203
    DOI: 10.1039/C2CC31037F

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