Issue 40, 2012
From the journal:

Chemical Communications

DNA tetraplex structure formation from human telomeric repeat motif (TTAGGG):(CCCTAA) in nanocavity water pools of reverse micelles†

Smritimoy Pramanik,a   Satoru Nagatoishia  and  Naoki Sugimoto*ab  

* Corresponding authors

a Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan
E-mail: sugimoto@konan-u.ac.jp
Fax: +81-78-303-1495
Tel: +81-78-303-1457

b Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan

Abstract

In an equimolar ratio the human telomeric oligonucleotides d[AGGG(TTAGGG)3] and d[(CCCTAA)3CCCT] formed mixed structures of duplex and tetraplex in bis(2-ethylhexyl)sulfosuccinate reverse micelles; only the duplex was observed in aqueous buffer. This finding suggests that heterogeneous confined media in the cell nucleus might induce a significant fraction of the telomeric region of genomic DNA to adopt non-canonical tetraplex structure.

Graphical abstract: DNA tetraplex structure formation from human telomeric repeat motif (TTAGGG):(CCCTAA) in nanocavity water pools of reverse micelles

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Article information

DOI
https://doi.org/10.1039/C2CC30622K
Article type
Communication
Submitted
28 Jan 2012
Accepted
09 Mar 2012
First published
09 Mar 2012

Chem. Commun., 2012,48, 4815-4817

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DNA tetraplex structure formation from human telomeric repeat motif (TTAGGG):(CCCTAA) in nanocavity water pools of reverse micelles

S. Pramanik, S. Nagatoishi and N. Sugimoto, Chem. Commun., 2012, 48, 4815 DOI: 10.1039/C2CC30622K

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