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Issue 31, 2012
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A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic

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Abstract

A synthetic scaffold that mimics a peptide β-strand has been designed and synthesised based on a 1,3-phenyl-linked hydantoin oligomer. The conformational preferences of this oligomer were investigated using molecular modelling and solution NMR experiments and suggest a planar conformation that accurately mimics the i, i + 2 and i + 4 residues of a peptide β-strand.

Graphical abstract: A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic

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Article information


Submitted
13 Jan 2012
Accepted
16 Feb 2012
First published
17 Feb 2012

Chem. Commun., 2012,48, 3709-3711
Article type
Communication

A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic

A. G. Jamieson, D. Russell and A. D. Hamilton, Chem. Commun., 2012, 48, 3709
DOI: 10.1039/C2CC30295K

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