Issue 26, 2012
From the journal:

Chemical Communications

The role of aristolochene synthase in diphosphate activation†

Juan A. Faraldos,‡a   Veronica Gonzalez‡a  and  Rudolf K. Allemann*a  

* Corresponding authors

a School of Chemistry, Cardiff University, Main Building, Park Place, UK
E-mail: allemannrk@cardiff.ac.uk
Fax: +44 (0)29 208 74030

Abstract

Analysis of the role of amino acids involved in diphosphate binding in the Michaelis complex of aristolochene synthase from P. roqueforti (PR-AS) reveals mechanistic details about leaving group (PPi) activation and the nature of the active site acid.

Graphical abstract: The role of aristolochene synthase in diphosphate activation

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Article information

DOI
https://doi.org/10.1039/C2CC17588F
Article type
Communication
Submitted
05 Dec 2011
Accepted
03 Feb 2012
First published
06 Feb 2012

Chem. Commun., 2012,48, 3230-3232

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The role of aristolochene synthase in diphosphate activation

J. A. Faraldos, V. Gonzalez and R. K. Allemann, Chem. Commun., 2012, 48, 3230 DOI: 10.1039/C2CC17588F

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