Issue 16, 2012
From the journal:

Chemical Communications

Captured at last: a catalyst–substrate adduct and a Rh-dihydride solvate in the asymmetric hydrogenation by a Rh-monophosphine catalyst†

Ilya D. Gridnev,*a   Elisabetta Albericob  and  Serafino Gladiali*c  

* Corresponding authors

a Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8552, Japan
E-mail: gridnev.i.aa@m.titech.ac.jp

b Istituto di Chimica Biomolecolare Consiglio Nazionale delle Ricerche trav. La Crucca n. 3, Li Punti, 07040 Sassari, Italy
E-mail: elisabetta.alberico@cnr.it

c Dipartimento di Chimica, University of Sassari, via Vienna 2, 07100 Sassari, Italy
E-mail: gladiali@uniss.it

Abstract

The mechanism of asymmetric hydrogenation catalyzed by [Rh(NBD)((R)-PhenylBinepine)2]SbF61 has been studied by NMR experiments and DFT computations. Either the low-temperature hydrogenation of the catalyst–substrate adduct 4 or the reaction of solvate dihydride 6 with MAC produced the hydrogenation product with over 99% ee (S).

Graphical abstract: Captured at last: a catalyst–substrate adduct and a Rh-dihydride solvate in the asymmetric hydrogenation by a Rh-monophosphine catalyst

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Article information

DOI
https://doi.org/10.1039/C2CC17335B
Article type
Communication
Submitted
24 Nov 2011
Accepted
16 Dec 2011
First published
20 Dec 2011

Chem. Commun., 2012,48, 2186-2188

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Captured at last: a catalyst–substrate adduct and a Rh-dihydride solvate in the asymmetric hydrogenation by a Rh-monophosphine catalyst

I. D. Gridnev, E. Alberico and S. Gladiali, Chem. Commun., 2012, 48, 2186 DOI: 10.1039/C2CC17335B

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