Issue 24, 2012

Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks

Abstract

The peptide AAKLVFF assembles into fibrils in water and nanotubes in methanol. Solid-state NMR data are consistent with fibrils constructed from β-sheet bilayers and nanotubes bounded by a wall of offset β-sheet monolayers. Remarkably distinct morphologies are thus traced to subtle differences in the arrangement of the same fundamental building blocks.

Graphical abstract: Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks

Supplementary files

Article information

Article type
Communication
Submitted
16 Nov 2011
Accepted
21 Jan 2012
First published
23 Jan 2012

Chem. Commun., 2012,48, 2976-2978

Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks

J. Madine, H. A. Davies, C. Shaw, I. W. Hamley and D. A. Middleton, Chem. Commun., 2012, 48, 2976 DOI: 10.1039/C2CC17118J

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