Issue 25, 2012
From the journal:

Chemical Communications

In situ monitoring of the DNA hybridization by attenuated total reflection surface-enhanced infrared absorption spectroscopy†

Jian-Yun Xu,a   Bo Jin,a   Yun Zhao,a   Kang Wang*a  and  Xing-Hua Xia*a  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
E-mail: xhxia@nju.edu.cn, wangkang@nju.edu.cn
Fax: +86-25-83685947
Tel: +86-25-83597436

Abstract

In situ monitoring of DNA hybridization kinetics is achieved via an attenuated total reflection surface-enhanced infrared absorption spectroscopy (ATR-SEIRAS) technique using a sandwich assay structure. The synergistic enhancement effect gives this ATR-SEIRAS-based detection strategy promise to be a convenient and unique platform for bioanalysis.

Graphical abstract: In situ monitoring of the DNA hybridization by attenuated total reflection surface-enhanced infrared absorption spectroscopy

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Article information

DOI
https://doi.org/10.1039/C2CC17058B
Article type
Communication
Submitted
14 Nov 2011
Accepted
16 Dec 2011
First published
20 Dec 2011

Chem. Commun., 2012,48, 3052-3054

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In situ monitoring of the DNA hybridization by attenuated total reflection surface-enhanced infrared absorption spectroscopy

J. Xu, B. Jin, Y. Zhao, K. Wang and X. Xia, Chem. Commun., 2012, 48, 3052 DOI: 10.1039/C2CC17058B

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