Issue 8, 2012

Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography

Abstract

A prototype sphingomyelin stationary phase for Immobilized Artificial Membrane (IAM) chromatography was synthesized by an ultra-short, solid-phase inspired methodology, in which an oxidative release monitoring strategy played a vital role. Evaluated in a proof-of-concept model for blood–brain barrier passage, partial least squares regression demonstrated its potential as an in vitro prediction tool.

Graphical abstract: Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography

Supplementary files

Article information

Article type
Communication
Submitted
06 Nov 2011
Accepted
29 Nov 2011
First published
29 Nov 2011

Chem. Commun., 2012,48, 1162-1164

Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography

D. Verzele, F. Lynen, M. D. Vrieze, A. G. Wright, M. Hanna-Brown and P. Sandra, Chem. Commun., 2012, 48, 1162 DOI: 10.1039/C2CC16872C

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