Issue 28, 2012
From the journal:

Chemical Communications

A dual cytotoxic and anti-angiogenic water-soluble gold(iii) complex induces endoplasmic reticulum damage in HeLa cells†

Jing-Jing Zhang,a   Raymond Wai-Yin Suna  and  Chi-Ming Che*a  

* Corresponding authors

a Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong
E-mail: cmche@hku.hk
Fax: +852 2857 1586
Tel: +852 2859 2154

Abstract

The water-soluble gold(III) complex [AuIII(butyl-C⁁N)biguanide]Cl (butyl-HC⁁N = 2-(4-n-butylphenyl)pyridine, BCN) displays cytotoxicity through S-phase cell cycle arrest and endoplasmic reticulum (ER) damage in HeLa cells, and shows a promising anti-angiogenic effect at sub-cytotoxic concentrations.

Graphical abstract: A dual cytotoxic and anti-angiogenic water-soluble gold(iii) complex induces endoplasmic reticulum damage in HeLa cells

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Article information

DOI
https://doi.org/10.1039/C2CC00029F
Article type
Communication
Submitted
03 Jan 2012
Accepted
14 Feb 2012
First published
14 Feb 2012

Chem. Commun., 2012,48, 3388-3390

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A dual cytotoxic and anti-angiogenic water-soluble gold(III) complex induces endoplasmic reticulum damage in HeLa cells

J. Zhang, R. W. Sun and C. Che, Chem. Commun., 2012, 48, 3388 DOI: 10.1039/C2CC00029F

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