Issue 1, 2012
From the journal:

Chemical Communications

Green chemistry: solvent- and metal-free Prins cyclization. Application to sequential reactions†

Damien Clarisse,a   Béatrice Pelotier,a   Olivier Pivaa  and  Fabienne Fache*a  

* Corresponding authors

a Université de Lyon, Université Lyon 1, ICBMS, équipe SURCOOF, CNRS, UMR 5246, Bât. Raulin, 43 Bd du 11 Nov. 1918, 69622 Villeurbanne cedex, France
E-mail: fache@univ-lyon1.fr
Fax: +33 472448136
Tel: +33472448521

Abstract

Prins cyclization between a homoallylic alcohol and an aldehyde, promoted by trimethylsilyl halide, afforded 4-halo-tetrahydropyrans with good to excellent yields. Thanks to the absence of the solvent and metal, the THP thus obtained have been implicated without purification in several other reactions, in a sequential way, affording in particular new indole derivatives.

Graphical abstract: Green chemistry: solvent- and metal-free Prins cyclization. Application to sequential reactions

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Article information

DOI
https://doi.org/10.1039/C1CC16501A
Article type
Communication
Submitted
19 Oct 2011
Accepted
21 Oct 2011
First published
21 Oct 2011

Chem. Commun., 2012,48, 157-159

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Green chemistry: solvent- and metal-free Prins cyclization. Application to sequential reactions

D. Clarisse, B. Pelotier, O. Piva and F. Fache, Chem. Commun., 2012, 48, 157 DOI: 10.1039/C1CC16501A

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