Issue 6, 2012
From the journal:

Chemical Communications

In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes†‡

Faustine Dubar,a   Sylvain Bohic,*bc   Christian Slomianny,d   Jean-Charles Morin,e   Patrick Thomas,e   Hadidjatou Kalamou,f   Yann Guérardel,g   Peter Cloetens,c   Jamal Khalifef  and  Christophe Biot*g  

* Corresponding authors

a Université Lille Nord de France, Université Lille1, UCCS—UMR CNRS 8181, 59652 Villeneuve d'Ascq Cedex, France

b Inserm, U836, équipe 6 «Rayonnement synchrotron et recherches médicales», Grenoble Institut des Neurosciences, 38054 Grenoble, France

c ESRF Facility, ESRF, BP220, Grenoble, France
E-mail: bohic@esrf.fr
Tel: +33-476882852

d Université Lille1, Inserm U1003—Laboratoire de Physiologie Cellulaire, Bâtiment SN3, 59655 Villeneuve d'Ascq Cédex, France

e IPL Santé, Environnement Durable, 1 rue du Professeur Calmette, 59046 Lille Cedex, France

f CIIL, Inserm U 1019, UMR CNRS 8024 Université Lille Nord de France, Institut Pasteur de Lille, 1 rue du Pr Calmette, 59019 Lille Cedex, France

g Université Lille Nord de France, Université Lille1, UGSF, CNRS UMR 8576, IFR 147, 59650 Villeneuve d'Ascq Cédex, France
E-mail: christophe.biot@univ-lille1.fr
Tel: +33-32043694

Abstract

We report here for the first time the in vitrolocalization of unlabeled antimalarial drugs with high spatial resolution. This strategy further enhances our understanding of the action mechanisms of antimalarial drugs. Our approach may be applied to a wide range of domains where quantitative chemical imaging of drugs at the sub-cellular level appears critical.

Graphical abstract: In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes

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Article information

DOI
https://doi.org/10.1039/C1CC16211J
Article type
Communication
Submitted
06 Oct 2011
Accepted
18 Nov 2011
First published
21 Nov 2011

Chem. Commun., 2012,48, 910-912

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In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes

F. Dubar, S. Bohic, C. Slomianny, J. Morin, P. Thomas, H. Kalamou, Y. Guérardel, P. Cloetens, J. Khalife and C. Biot, Chem. Commun., 2012, 48, 910 DOI: 10.1039/C1CC16211J

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