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Issue 4, 2012
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Site-selective modification of proteins for the synthesis of structurally defined multivalent scaffolds

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Abstract

A combination of classical site-directed mutagenesis, genetic code engineering and bioorthogonal reactions delivered a chemically modified barstar protein with one or four carbohydrates installed at specific residues. These protein conjugates were employed in multivalent binding studies, which support the use of proteins as structurally defined scaffolds for the presentation of multivalent ligands.

Graphical abstract: Site-selective modification of proteins for the synthesis of structurally defined multivalent scaffolds

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Supplementary files

Article information


Submitted
28 Sep 2011
Accepted
17 Oct 2011
First published
09 Nov 2011

Chem. Commun., 2012,48, 522-524
Article type
Communication

Site-selective modification of proteins for the synthesis of structurally defined multivalent scaffolds

L. M. Artner, L. Merkel, N. Bohlke, F. Beceren-Braun, C. Weise, J. Dernedde, N. Budisa and C. P. R. Hackenberger, Chem. Commun., 2012, 48, 522
DOI: 10.1039/C1CC16039G

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