Label-free visual detection of nucleic acids in biological samples with single-base mismatch detection capability

Yanling Song; Weiting Zhang; Yuan An; Liang Cui; Chundong Yu; Zhi Zhu; Chaoyong James Yang

doi:10.1039/C1CC15777A

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Label-free visual detection of nucleic acids in biological samples with single-base mismatch detection capability†

Yanling Song,^a Weiting Zhang,^a Yuan An,^b Liang Cui,^a Chundong Yu,^b Zhi Zhu*^a and Chaoyong James Yang*^a

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* Corresponding authors

^a State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province, The Key Laboratory of Analytical Science, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, China
E-mail: zhuzhi@xmu.edu.cn, cyyang@xmu.edu.cn

^b State Key Laboratory of Cellular Stress Biology, College of life Sciences, Xiamen University, Xiamen, Fujian, China

Abstract

We have combined an allosteric molecular beacon for target recognition and guanine-rich DNAzyme for signal amplification to develop a new platform for visual detection of nucleic acids with single-base mismatch detection capability. The fully DNA-structured platform can undergo color change in response to target DNA/RNA, which enables sensitive and selective visual detection in biological samples.

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Article information

DOI: https://doi.org/10.1039/C1CC15777A
Article type: Communication
Submitted: 18 Sep 2011
Accepted: 19 Oct 2011
First published: 07 Nov 2011

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Chem. Commun., 2012,48, 576-578

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Label-free visual detection of nucleic acids in biological samples with single-base mismatch detection capability

Y. Song, W. Zhang, Y. An, L. Cui, C. Yu, Z. Zhu and C. J. Yang, Chem. Commun., 2012, 48, 576 DOI: 10.1039/C1CC15777A

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Chemical Communications

Label-free visual detection of nucleic acids in biological samples with single-base mismatch detection capability†

Abstract

Supplementary files

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Label-free visual detection of nucleic acids in biological samples with single-base mismatch detection capability

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