Issue 5, 2012
From the journal:

Chemical Communications

Label-free and sensitive thrombin sensing on a molecularly grafted aptamer on graphene†

Yanping Wang,a   Yinghong Xiao,*a   Xiaoling Ma,b   Na Lia  and  Xiaodi Yang*a  

* Corresponding authors

a Jiangsu Key Laboratory of New Power Batteries, Jiangsu Key Laboratory of Biofunctional Materials, Laboratory of Electrochemistry, College of Chemistry and Material Science, Nanjing Normal University, Nanjing 210097, China
E-mail: yhxiao@njnu.edu.cn
Fax: +86 25-85891536
Tel: +86 25-85891536

b Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing 210097, China
E-mail: yangxiaodi@njnu.edu.cn
Fax: +86 25-83598280
Tel: +86 25-83598648

Abstract

A unique nanocomposite was constructed by grafting an aptamer on graphene and used as a label-free biosensor for thrombin sensing, showing good selectivity, a low detection limit of 0.45 fM and high sensitivity, with a linear response up to 100 fM.

Graphical abstract: Label-free and sensitive thrombin sensing on a molecularly grafted aptamer on graphene

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Article information

DOI
https://doi.org/10.1039/C1CC15429J
Article type
Communication
Submitted
01 Sep 2011
Accepted
09 Nov 2011
First published
25 Nov 2011

Chem. Commun., 2012,48, 738-740

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Label-free and sensitive thrombin sensing on a molecularly grafted aptamer on graphene

Y. Wang, Y. Xiao, X. Ma, N. Li and X. Yang, Chem. Commun., 2012, 48, 738 DOI: 10.1039/C1CC15429J

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