Issue 14, 2012
From the journal:

Chemical Communications

Ultra-selective and sensitive DNA detection by a universal apurinic/apyrimidinic probe-based endonuclease IV signal amplification system†

Xianjin Xiao,a   Chen Song,a   Chen Zhang,a   Xin Sua  and  Meiping Zhao*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
E-mail: mpzhao@pku.edu.cn
Fax: +86 10-62751708

Abstract

A novel signal amplification system that is applicable to any DNA sequence of interest has been developed by using a combination of apurinic/apyrimidinic probe and endonuclease IV. The system allows rapid, highly selective and sensitive detection of target DNA sequences at very low concentrations (10 fmol) or low abundance levels (1%).

Graphical abstract: Ultra-selective and sensitive DNA detection by a universal apurinic/apyrimidinic probe-based endonuclease IV signal amplification system

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Article information

DOI
https://doi.org/10.1039/C1CC15360A
Article type
Communication
Submitted
29 Aug 2011
Accepted
12 Oct 2011
First published
25 Oct 2011

Chem. Commun., 2012,48, 1964-1966

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Ultra-selective and sensitive DNA detection by a universal apurinic/apyrimidinic probe-based endonuclease IV signal amplification system

X. Xiao, C. Song, C. Zhang, X. Su and M. Zhao, Chem. Commun., 2012, 48, 1964 DOI: 10.1039/C1CC15360A

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