Chiral discrimination and enantiomeric composition analysis of quinine and quinidine based on paper substrate room temperature phosphorescence

Abstract

Based on paper substrate room temperature phosphorescence, the chiral discrimination of quinine and quinidine was achieved using Whatman No. 40 filter paper as the substrate and Pb(Ac)₂ as the heavy atom perturber. The phosphorescence lifetime differences between quinine and quinidine increased from 4.45% to 27.90% upon addition of (+)-tartaric acid as the chiral modifier. This provided a rapid and simple method for the determination of the enantiomeric composition of quinine and quinidine.