Issue 12, 2012
From the journal:

Analytical Methods

Chromatographic behavior of the biologically active proline derivativecaptopril on particulate, monolithic and core–shell narrow bore columns

Constantinos K. Zacharis,ab   Theano D. Karakosta,a   Paraskevas D. Tzanavaras,*a   Pantelis G. Rigasc  and  Demetrius G. Themelisa  

* Corresponding authors

a Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
E-mail: ptzanava@chem.auth.gr
Fax: +30 2310 997719
Tel: +30 2310 997721

b Research Laboratory for the Physical and Chemical Testing of Foods, Department of Food Technology, School of Food Technology and Nutrition, Alexander Technological Educational Institute (ATEI) of Thessaloniki, Thessaloniki, Greece

c Biotoxins and Analytical Chemistry Laboratory, Department of Fisheries and Aquaculture Technology, Alexander Technological Educational Institute of Thessaloniki, N. Moudania, Greece

Abstract

In the present work, the chromatographic behavior of the proline derivative captopril was studied on three different kinds of stationary phases. Four narrow-bore analytical columns were used in this study including particulate, monolithic, and two fused-core columns. The secondary equilibrium distribution of captopril and the peak shape were investigated at different mobile phase pH values and column temperatures. Under selected chromatographic conditions (pH: 2.5, 50 °C) where a single peak of captopril was obtained the performance of the studied narrow bore columns was compared.

Graphical abstract: Chromatographic behavior of the biologically active proline derivative captopril on particulate, monolithic and core–shell narrow bore columns

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Article information

DOI
https://doi.org/10.1039/C2AY26031J
Article type
Technical Note
Submitted
08 Jul 2012
Accepted
04 Oct 2012
First published
04 Oct 2012

Anal. Methods, 2012,4, 4373-4377

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Chromatographic behavior of the biologically active proline derivative captopril on particulate, monolithic and core–shell narrow bore columns

C. K. Zacharis, T. D. Karakosta, P. D. Tzanavaras, P. G. Rigas and D. G. Themelis, Anal. Methods, 2012, 4, 4373 DOI: 10.1039/C2AY26031J

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