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Issue 6, 2012
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A sensitive chemiluminescence determination of isoproterenol in pharmaceutical and human serum using luminol–diperiodatoargentate(iii) system

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Abstract

A novel injection analysis-direct chemiluminescence (CL) method has been developed for rapid, sensitive and simple determination of isoproterenol (ISP) in pharmaceutical and human serum samples. The method is based on the enhancement effect of ISP on CL signal of the reaction system, luminol–diperiodatoargentate(III) in alkaline solution. Under optimum conditions, the CL intensity of luminol–diperiodatoargentate(III) is proportional to ISP concentration in the range of 1.0 × 10−8 to 9.0 × 10−7 mol L−1. The detection limit was found as 4.7 × 10−9 mol L−1 ISP, and the relative standard deviation for eleven replicated measurements of 2.0 × 10−7 mol L−1 ISP was 2.7%. The reaction mechanism for the CL reaction is proposed and discussed.

Graphical abstract: A sensitive chemiluminescence determination of isoproterenol in pharmaceutical and human serum using luminol–diperiodatoargentate(iii) system

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Article information


Submitted
26 Jun 2011
Accepted
17 Nov 2011
First published
22 Dec 2011

Anal. Methods, 2012,4, 1573-1578
Article type
Paper

A sensitive chemiluminescence determination of isoproterenol in pharmaceutical and human serum using luminol–diperiodatoargentate(III) system

B. Rezaei, A. A. Ensafi and F. Haghighatnia, Anal. Methods, 2012, 4, 1573
DOI: 10.1039/C2AY05381K

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