Issue 17, 2012

Toward CMOS image sensor based glucose monitoring

Abstract

Complementary metal oxide semiconductor (CMOS) image sensor is a powerful tool for biosensing applications. In this present study, CMOS image sensor has been exploited for detecting glucose levels by simple photon count variation with high sensitivity. Various concentrations of glucose (100 mg dL−1 to 1000 mg dL−1) were added onto a simple poly-dimethylsiloxane (PDMS) chip and the oxidation of glucose was catalyzed with the aid of an enzymatic reaction. Oxidized glucose produces a brown color with the help of chromogen during enzymatic reaction and the color density varies with the glucose concentration. Photons pass through the PDMS chip with varying color density and hit the sensor surface. Photon count was recognized by CMOS image sensor depending on the color density with respect to the glucose concentration and it was converted into digital form. By correlating the obtained digital results with glucose concentration it is possible to measure a wide range of blood glucose levels with great linearity based on CMOS image sensor and therefore this technique will promote a convenient point-of-care diagnosis.

Graphical abstract: Toward CMOS image sensor based glucose monitoring

Article information

Article type
Communication
Submitted
05 Apr 2012
Accepted
22 Jun 2012
First published
25 Jun 2012

Analyst, 2012,137, 3917-3920

Toward CMOS image sensor based glucose monitoring

J. P. Devadhasan and S. Kim, Analyst, 2012, 137, 3917 DOI: 10.1039/C2AN35458F

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