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Issue 10, 2012
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Au@SiO2 core–shell nanoparticles for laser desorption/ionization time of flight mass spectrometry

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Abstract

In matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS), the analysis capability, especially for small molecules, is often compromised by the addition of organic matrices due to the existence of background signals. Herein we report a new detection method on the utility of core–shell nanoparticles (CSNPs) as energy transfer structure in LDI-TOF-MS. The LDI-TOF-MS based on gold–silica core–shell nanoparticles with ultrathin silica shell of 2–4 nm (Au@utSiO2 CSNPs) was effectively applied to the analysis of many compounds, especially for small functional molecules and polymers, which was more promising than MALDI-TOF-MS.

Graphical abstract: Au@SiO2 core–shell nanoparticles for laser desorption/ionization time of flight mass spectrometry

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Supplementary files

Article information


Submitted
14 Jan 2012
Accepted
12 Mar 2012
First published
13 Mar 2012

Analyst, 2012,137, 2454-2458
Article type
Paper

Au@SiO2 core–shell nanoparticles for laser desorption/ionization time of flight mass spectrometry

X. Zhu, L. Wu, D. C. Mungra, S. Xia and J. Zhu, Analyst, 2012, 137, 2454
DOI: 10.1039/C2AN35074B

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