Issue 2, 2012

Development and applications of a microfluidic reactor with multiple analytical probes

Abstract

We report the development of a versatile microfluidic (MF) reactor with multiple analytical probes, which can be used for (i) quantitative characterisation of molecular vibrational signatures of reactants or products, (ii) the localised real-time monitoring of temperature and (iii) site-specific measurements of pH of the reaction system. The analytical probes utilised for in situ reaction analysis include an ATR-FTIR probe, a temperature probe, and a pH probe. We demonstrate the applications of the MF reactor with integrated probes for the parallel monitoring of multiple variables in acid/base neutralisation reaction, of changes in buffer pH, temperature, and vibrational absorption bands, and for monitoring the kinetics of the reaction between CO2 and a buffer system with therapeutic applications.

Graphical abstract: Development and applications of a microfluidic reactor with multiple analytical probes

Supplementary files

Article information

Article type
Paper
Submitted
08 Oct 2011
Accepted
29 Oct 2011
First published
23 Nov 2011

Analyst, 2012,137, 444-450

Development and applications of a microfluidic reactor with multiple analytical probes

J. Greener, E. Tumarkin, M. Debono, C. Kwan, M. Abolhasani, A. Guenther and E. Kumacheva, Analyst, 2012, 137, 444 DOI: 10.1039/C1AN15940B

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