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Issue 1, 2012
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Resonant Mie scattering (RMieS) correction applied to FTIR images of biological tissue samples

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Abstract

Recently a resonant Mie scattering (RMieS) correction approach has been developed and demonstrated to be effective for removing the baseline distortions that compromise the raw data in individual spectra. In this paper RMieS correction is extended to FTIR images of a tissue section from biopsy of the human cervical transformation zone and a coronal tissue section of a Wistar rat brain and compared to the uncorrected images. It is shown that applying RMieS correction to FTIR images a) removes baseline distortions from the image spectra and thus reveals previously hidden information on spatial variation of chemical contents within the tissue and b) can lead to improved automatic tissue feature classification through multivariate cluster analysis.

Graphical abstract: Resonant Mie scattering (RMieS) correction applied to FTIR images of biological tissue samples

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Publication details

The article was received on 21 Jul 2011, accepted on 21 Oct 2011 and first published on 10 Nov 2011


Article type: Paper
DOI: 10.1039/C1AN15628D
Citation: Analyst, 2012,137, 126-132
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    Resonant Mie scattering (RMieS) correction applied to FTIR images of biological tissue samples

    K. R. Bambery, B. R. Wood and D. McNaughton, Analyst, 2012, 137, 126
    DOI: 10.1039/C1AN15628D

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