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Issue 19, 2011
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Multicompartment polymersome gel for encapsulation

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Abstract

We introduce an approach that combines the concepts of emulsion-templating and dewetting for fabricating polymersomes with a large number of compartments. The resultant polymersome gel behaves as a gel-like solid, but is a true vesicle suspended in an aqueous environment. Due to the thin membranes that separate the compartments, the polymersome gels have a high volume fraction of internal phase for encapsulation of hydrophilic actives; they also provide a large surface area of diblock copolymer membrane for encapsulation of lipophilic actives. Multiple actives can also be encapsulated in the gel without cross-contamination. Our technique represents a simple and versatile bulk approach for fabricating polymersome gels; it does not require the use of any specialized equipment or subsequent polymerization steps to solidify the gel. The resultant polymersome gel is promising as an encapsulating structure as well as a scaffold for tissue engineering.

Graphical abstract: Multicompartment polymersome gel for encapsulation

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Publication details

The article was received on 02 Jun 2011, accepted on 05 Aug 2011 and first published on 19 Aug 2011


Article type: Communication
DOI: 10.1039/C1SM06026K
Citation: Soft Matter, 2011,7, 8762-8765
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    Multicompartment polymersome gel for encapsulation

    H. C. Shum and D. A. Weitz, Soft Matter, 2011, 7, 8762
    DOI: 10.1039/C1SM06026K

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