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Issue 18, 2011
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Self-assembled liposomes from amphiphilic electrospun nanofibers

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Amphiphilic nanofibers composed of the hydrophilic polymer polyvinylpyrrolidone K60 (PVP) and soybean lecithin were fabricated using an electrospinning process. As a result of the templating and confinement properties of the nanofibers, phosphatidyl choline (PC) liposomes were spontaneously formed through molecular self-assembly when the fibers were added to water. The sizes of the self-assembled liposomes could be manipulated by varying the content of PC in the nanofibers (over the range 9.1–33.3% (w/w) in the present study). The influence of PC on nanofiber formation, and a possible mechanism of templated liposome formation are discussed. This facile and convenient strategy for manipulating molecular self-assembly to synthesize liposomes provides a versatile new approach for the development of novel drug delivery systems and biomaterials.

Graphical abstract: Self-assembled liposomes from amphiphilic electrospun nanofibers

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Publication details

The article was received on 24 May 2011, accepted on 29 Jun 2011 and first published on 03 Aug 2011

Article type: Paper
DOI: 10.1039/C1SM05961K
Citation: Soft Matter, 2011,7, 8239-8247
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    Self-assembled liposomes from amphiphilic electrospun nanofibers

    D. Yu, C. Branford-White, G. R. Williams, S. W. A. Bligh, K. White, L. Zhu and N. P. Chatterton, Soft Matter, 2011, 7, 8239
    DOI: 10.1039/C1SM05961K

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