Jump to main content
Jump to site search

Issue 18, 2011
Previous Article Next Article

Self-assembled liposomes from amphiphilic electrospun nanofibers

Author affiliations

Abstract

Amphiphilic nanofibers composed of the hydrophilic polymer polyvinylpyrrolidone K60 (PVP) and soybean lecithin were fabricated using an electrospinning process. As a result of the templating and confinement properties of the nanofibers, phosphatidyl choline (PC) liposomes were spontaneously formed through molecular self-assembly when the fibers were added to water. The sizes of the self-assembled liposomes could be manipulated by varying the content of PC in the nanofibers (over the range 9.1–33.3% (w/w) in the present study). The influence of PC on nanofiber formation, and a possible mechanism of templated liposome formation are discussed. This facile and convenient strategy for manipulating molecular self-assembly to synthesize liposomes provides a versatile new approach for the development of novel drug delivery systems and biomaterials.

Graphical abstract: Self-assembled liposomes from amphiphilic electrospun nanofibers

Back to tab navigation

Publication details

The article was received on 24 May 2011, accepted on 29 Jun 2011 and first published on 03 Aug 2011


Article type: Paper
DOI: 10.1039/C1SM05961K
Citation: Soft Matter, 2011,7, 8239-8247
  •   Request permissions

    Self-assembled liposomes from amphiphilic electrospun nanofibers

    D. Yu, C. Branford-White, G. R. Williams, S. W. A. Bligh, K. White, L. Zhu and N. P. Chatterton, Soft Matter, 2011, 7, 8239
    DOI: 10.1039/C1SM05961K

Search articles by author

Spotlight

Advertisements