Issue 20, 2011
From the journal:

Soft Matter

Calcium ions as bioinspired triggers to reversibly control the coil-to-helix transition in peptide-polymer conjugates†

Romina I. Kühnle,a   Denis Gebauerb  and  Hans G. Börner*a  

* Corresponding authors

a Humboldt-Universität zu Berlin, Department of Chemistry, Laboratory of Organic Synthesis of Functional Systems, Brook-Taylor-Str. 2, Berlin, Germany
E-mail: h.boerner@hu-berlin.de
Fax: +49 30 20937500
Tel: +49 30 20937348

b Universität Konstanz, Department of Chemistry, Physical Chemistry, Universitätsstr. 10, Konstanz, Germany

Abstract

Controlling a coil-to-helix transition in peptide–polymer conjugates with soft stimuli requires the careful balancing of stabilizing and destabilizing effects in the peptide segment. The transition between two secondary structures of a bioconjugate is realized using calcium ions to establish a biomimetic control mechanism. Regulation of Ca2+-ion levels via competitive Ca2+-ion binders made the process reversible.

Graphical abstract: Calcium ions as bioinspired triggers to reversibly control the coil-to-helix transition in peptide-polymer conjugates

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Article information

DOI
https://doi.org/10.1039/C1SM05625E
Article type
Communication
Submitted
08 Apr 2011
Accepted
24 May 2011
First published
09 Jun 2011

Soft Matter, 2011,7, 9616-9619

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Calcium ions as bioinspired triggers to reversibly control the coil-to-helix transition in peptide-polymer conjugates

R. I. Kühnle, D. Gebauer and H. G. Börner, Soft Matter, 2011, 7, 9616 DOI: 10.1039/C1SM05625E

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