Jump to main content
Jump to site search

Issue 13, 2011
Previous Article Next Article

Size-dependent detachment of DNA molecules from liquid–liquid interfaces

Author affiliations

Abstract

Binary aqueous solutions of poly(ethylene glycol) (PEG) and dextran form two phases with a liquid–liquid interface at which DNA molecules can be accumulated using an electric field. Studying DNA strands of different lengths reveals that the interface acts as a size-selective filter for molecules. Upon increasing the electric field strength, the small molecules are first detached from the interface, followed by the larger ones. Besides the contributions to a better understanding of the interaction of nanoscopic objects with liquid–liquid interfaces, the work demonstrates novel pathways for the size separation of DNA. We anticipate that by optimizing the parameters governing the detachment of molecules or nanoparticles, superior schemes for DNA separation or concepts of functional liquid interfaces could emerge.

Graphical abstract: Size-dependent detachment of DNA molecules from liquid–liquid interfaces

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Feb 2011, accepted on 06 May 2011 and first published on 02 Jun 2011


Article type: Paper
DOI: 10.1039/C1SM05309D
Soft Matter, 2011,7, 6320-6326

  •   Request permissions

    Size-dependent detachment of DNA molecules from liquid–liquid interfaces

    T. Hahn and S. Hardt, Soft Matter, 2011, 7, 6320
    DOI: 10.1039/C1SM05309D

Search articles by author

Spotlight

Advertisements