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Issue 5, 2011
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Minimum-energy vesicle and cell shapes calculated using spherical harmonics parameterization

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Abstract

An important open question in biophysics is to understand how mechanical forces shape membrane-bounded cells and their organelles. A general solution to this problem is to calculate the bending energy of an arbitrarily shaped membrane surface, which can include both lipids and cytoskeletal proteins, and minimize the energy subject to all mechanical constraints. However, the calculations are difficult to perform, especially for shapes that do not possess axial symmetry. We show that the spherical harmonics parameterization (SHP) provides an analytic description of shape that can be used to quickly and reliably calculate minimum energy shapes of both symmetric and asymmetric surfaces. Using this method, we probe the entire set of shapes predicted by the bilayer couple model, unifying work based on different computational approaches, and providing additional details of the transitions between different shape classes. In addition, we present new minimum-energy morphologies based on non-linear models of membrane skeletal elasticity that closely mimic extreme shapes of red blood cells. The SHP thus provides a versatile shape description that can be used to investigate forces that shape cells.

Graphical abstract: Minimum-energy vesicle and cell shapes calculated using spherical harmonics parameterization

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Publication details

The article was received on 23 Oct 2010, accepted on 08 Dec 2010 and first published on 21 Jan 2011


Article type: Paper
DOI: 10.1039/C0SM01193B
Citation: Soft Matter, 2011,7, 2138-2143
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    Minimum-energy vesicle and cell shapes calculated using spherical harmonics parameterization

    K. Khairy and J. Howard, Soft Matter, 2011, 7, 2138
    DOI: 10.1039/C0SM01193B

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